Structure of PDB 5tt8 Chain A

Receptor sequence
>5tt8A (length=201) Species: 85962 (Helicobacter pylori 26695) [Search protein sequence]
ENGPHRWDKLHKDFEVCKSGKSQSPINIEHYYHTQDKADLQFKYAASKAV
FFTHHTLKASFEPTNHINYRGHDYVLDNVHFHAPMEFLINNKTRPLSAHF
VHLVLAIGFEEGKENPNLDPILNFKEVALDAFLPKSINYYHFNGSLTAPP
CTEGVAWFVIEEPLEVSAKQLAEIKKRMKNSPNQRPVQPDYNTVIIKSSA
E
3D structure
PDB5tt8 Structure-Activity Relationship for Sulfonamide Inhibition of Helicobacter pylori alpha-Carbonic Anhydrase.
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H85 H110 H112 E116 H129 T191
Catalytic site (residue number reindexed from 1) H55 H80 H82 E86 H99 T147
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H110 H112 H129 H80 H82 H99
BS02 D8W A K88 D107 N108 H110 H112 H129 L190 T191 W201 K58 D77 N78 H80 H82 H99 L146 T147 W157 MOAD: Ki=315nM
PDBbind-CN: -logKd/Ki=6.50,Ki=315nM
Gene Ontology
Molecular Function
GO:0004089 carbonate dehydratase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:5tt8, PDBe:5tt8, PDBj:5tt8
PDBsum5tt8
PubMed28002963
UniProtA0A0M3KL20

[Back to BioLiP]