Structure of PDB 5tsp Chain A

Receptor sequence
>5tspA (length=448) Species: 195103 (Clostridium perfringens ATCC 13124) [Search protein sequence]
VEGAVKTEPVDLFHPGFLNSSNYRIPALFKTKEGTLIASIDARRQGGADA
PNNDIDTAVRRSEDGGKTWDEGQIIMDYPDKSSVIDTTLIQDDETGRIFL
LVTHFPSKYGFWNAGLGSGFKNIDGKEYLCLYDSSGKEFTVRENVVYDKD
GNKTEYTTNALGDLFRNGTKIDNINSSTAPLKAKGTSYINLVYSDDDGKT
WSEPQNINFQVKKDWMKFLGIAPGRGIQIKNGEHKGRIVVPVYYTNEKGK
QSSAVIYSDDSGKNWTIGESPNDNRKLENGKIINSKTLSDDAPQLTECQV
VEMPNGQLKLFMRNLSGYLNIATSFDGGATWDETVEKDTNVLEPYCQLSV
INYSQKIDGKDAVIFSNPNARSRSNGTVRIGLINQVGTYENGEPKYEFDW
KYNKLVKPGYYAYSCLTELSNGNIGLLYEGTPSEEMSYIEMNLKYLES
3D structure
PDB5tsp Crystal structure of the catalytic domain of Clostridium perfringens neuraminidase in complex with a non-carbohydrate-based inhibitor, 2-(cyclohexylamino)ethanesulfonic acid
ChainA
Resolution1.24 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A290 D291 E539 Y655
Catalytic site (residue number reindexed from 1) A48 D49 E297 Y413
Enzyme Commision number 3.2.1.18: exo-alpha-sialidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NHE A R266 D291 D328 F353 R555 R615 Y655 R24 D49 D86 F111 R313 R373 Y413
BS02 CA A D296 D298 D319 Y320 D54 D56 D77 Y78
Gene Ontology
Molecular Function
GO:0004308 exo-alpha-sialidase activity

View graph for
Molecular Function
External links
PDB RCSB:5tsp, PDBe:5tsp, PDBj:5tsp
PDBsum5tsp
PubMed28315686
UniProtA0A0H2YQR1

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