Structure of PDB 5ts5 Chain A

Receptor sequence
>5ts5A (length=483) Species: 8725 (Bothrops atrox) [Search protein sequence]
DDRNPLEECFRETDYEEFLEIAKNGLSTTSNPKRVVIVGAGMSGLSAAYV
LANAGHQVTVLEASERAGGRVKTYRNEKEGWYANLGPMRLPEKHRIVREY
IRKFDLQLNEFSQENENAWYFIKNIRKRVGEVNKDPGVLEYPVKPSEVGK
SAGQLYEESLQKAVEELRRTNCSYMLNKYDTYSTKEYLLKEGNLSPGAVD
MIGDLLNEDSGYYVSFIESLKHDDIFAYEKRFDEIVGGMDKLPTSMYQAI
QEKVHLNARVIKIQQDVKEVTVTYQTSEKETLSVTADYVIVCTTSRAARR
IKFEPPLPPKKAHALRSVHYRSGTKIFLTCTKKFWEDDGIHGGKSTTDLP
SRFIYYPNHNFPNGVGVIIAYGIGDDANYFQALDFEDCGDIVINDLSLIH
QLPKEEIQAICRPSMIQRWSLDKYAMGGITTFTPYQFQHFSEALTAPVDR
IYFAGEYTAQAHGWIDSTIKSGLRAARDVNRAS
3D structure
PDB5ts5 Crystal structure and molecular dynamics studies of L-amino acid oxidase from Bothrops atrox.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P92 H223 K326
Catalytic site (residue number reindexed from 1) P91 H222 K325
Enzyme Commision number 1.4.3.2: L-amino-acid oxidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A V39 G40 S44 L62 E63 A64 G70 R71 G87 P88 R90 R260 V261 T294 A298 Y372 W420 G429 I430 G456 E457 G464 W465 I466 T469 V38 G39 S43 L61 E62 A63 G69 R70 G86 P87 R89 R259 V260 T293 A297 Y371 W419 G428 I429 G455 E456 G463 W464 I465 T468
BS02 ZN A H314 H440 H313 H439
Gene Ontology
Molecular Function
GO:0001716 L-amino-acid oxidase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0090729 toxin activity
GO:0106329 L-phenylalaine oxidase activity
Biological Process
GO:0006915 apoptotic process
GO:0009063 amino acid catabolic process
GO:0031640 killing of cells of another organism
GO:0042742 defense response to bacterium
GO:0044478 envenomation resulting in positive regulation of platelet aggregation in another organism
GO:0044532 modulation of apoptotic process in another organism
GO:0050829 defense response to Gram-negative bacterium
GO:0050830 defense response to Gram-positive bacterium
GO:0090330 regulation of platelet aggregation
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ts5, PDBe:5ts5, PDBj:5ts5
PDBsum5ts5
PubMed28137621
UniProtP0CC17|OXLA_BOTAT L-amino-acid oxidase

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