Structure of PDB 5trf Chain A

Receptor sequence
>5trfA (length=98) Species: 9606 (Homo sapiens) [Search protein sequence]
TDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQ
YIMTKRLYQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
3D structure
PDB5trf SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7HC A V14 L54 L57 G58 I61 M62 Y67 F86 V93 H96 I99 Y100 V5 L45 L48 G49 I52 M53 Y58 F73 V80 H83 I86 Y87 MOAD: Ki=0.88nM
PDBbind-CN: -logKd/Ki=9.06,Ki=0.88nM
BindingDB: Ki=0.880000nM,Kd=2.7nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:5trf, PDBe:5trf, PDBj:5trf
PDBsum5trf
PubMed25145672
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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