Structure of PDB 5tq7 Chain A

Receptor sequence
>5tq7A (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHEHLR
DFEREIEILKSLQHDNIVKYKGVCYSAGNLKLIMEYLPYGSLRDYLQKHK
ERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDF
GLTKVLPQDKEYYKVESPIFWYAPESLTESKFSVASDVWSFGVVLYELFT
YIEKSKSPPAEFMRMIGSIVTHLIELLKNNGRLPRPDGCPDEIYMIMTEC
WNNNVNQRPSFRDLALRVDQVRDNMAG
3D structure
PDB5tq7 Design and Synthesis of a Pan-Janus Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin.
ChainA
Resolution2.1 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D976 A978 R980 N981 D994 S1016
Catalytic site (residue number reindexed from 1) D131 A133 R135 N136 D149 S167
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7GT A L855 K857 G858 G861 S862 V863 A880 Y931 L932 L983 D994 L15 K17 G18 G21 S22 V23 A40 Y86 L87 L138 D149 PDBbind-CN: -logKd/Ki=7.67,IC50=21.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5tq7, PDBe:5tq7, PDBj:5tq7
PDBsum5tq7
PubMed27983835
UniProtO60674|JAK2_HUMAN Tyrosine-protein kinase JAK2 (Gene Name=JAK2)

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