Structure of PDB 5tpx Chain A

Receptor sequence
>5tpxA (length=106) Species: 36329 (Plasmodium falciparum 3D7) [Search protein sequence]
GHKEVQLKDQILGVLDYLEKQQSAWPFLKPVSLSEAPDYYDIIKEPTDIL
TMRRKARHGDYKTKEDFGIELKRMFDNCRLYNAPTTIYFKYANELQTLIW
PKYEAI
3D structure
PDB5tpx Discovery of a PCAF Bromodomain Chemical Probe.
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7H7 A W1379 P1380 K1383 P1384 V1385 E1389 N1436 Y1442 W25 P26 K29 P30 V31 E35 N82 Y88 MOAD: Kd=280nM
PDBbind-CN: -logKd/Ki=6.55,Kd=280nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5tpx, PDBe:5tpx, PDBj:5tpx
PDBsum5tpx
PubMed27966810
UniProtQ8IB67

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