Structure of PDB 5tpa Chain A

Receptor sequence
>5tpaA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
NHLSIVTLEEAPFVIVEDIDETCVRNTVPCRKFVKINNSTNEGMNVKKCC
KGFCIDILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAV
MAVGSLTINEERSEVVDFSVPFVETGISVMVSRGTQVTGLSDKKFQRPHD
YSPPFRFGTVPNGSTERNIRNNYPYMHQYMTKFNQKGVEDALVSLKTGKL
DAFIYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYGIALQKGSPWKRQI
DLALLQFVGDGEMEELETLWLTGIC
3D structure
PDB5tpa GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile.
ChainA
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLU A H87 S113 T115 R120 G171 S172 T173 Y213 H79 S105 T107 R112 G163 S164 T165 Y205
BS02 7H2 A P129 F130 V131 E132 T242 G243 P121 F122 V123 E124 T234 G235 BindingDB: EC50=41nM
Gene Ontology
Molecular Function
GO:0015276 ligand-gated monoatomic ion channel activity
Cellular Component
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:5tpa, PDBe:5tpa, PDBj:5tpa
PDBsum5tpa
PubMed28105280
UniProtQ12879|NMDE1_HUMAN Glutamate receptor ionotropic, NMDA 2A (Gene Name=GRIN2A)

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