Structure of PDB 5tp0 Chain A

Receptor sequence
>5tp0A (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
IVGGYTCEENSLPYQVSLNSGSHFCGGSLISEQWVVSAAHCYKTRIQVRL
GEHNIKVLEGNEQFINAAKIIRHPKYNRDTLDNDIMLIKLSSPAVINARV
STISLPTAPPAAGTECLISGWGNTLSFGADYPDELKCLDAPVLTQAECKA
SYPGKITNSMFCVGFLEGGKDSCQRDSGGPVVCNGQLQGVVSWGHGCAWK
NRPGVYTKVYNYVDWIKDTIAANS
3D structure
PDB5tp0 Small molecule inhibitors of mesotrypsin from a structure-based docking screen.
ChainA
Resolution1.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 Q192 R193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H40 D84 Q174 R175 D176 S177 G178
Enzyme Commision number 3.4.21.4: trypsin.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E70 N72 V75 E80 E52 N54 V57 E62
BS02 BRN A D189 S190 C191 W215 G216 G219 C220 D171 S172 C173 W193 G194 G196 C197 MOAD: Ki=3.66uM
PDBbind-CN: -logKd/Ki=5.44,Ki=3.66uM
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5tp0, PDBe:5tp0, PDBj:5tp0
PDBsum5tp0
PubMed28463992
UniProtP35030|TRY3_HUMAN Trypsin-3 (Gene Name=PRSS3)

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