Structure of PDB 5toa Chain A

Receptor sequence
>5toaA (length=230) Species: 9606 (Homo sapiens) [Search protein sequence]
ALSPEQLVLTLLEAEPPHVLISRPAPFTEASMMMSLTKLADKELVHMISW
AKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDLVL
DRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYD
SSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNK
GMEHLLNMKCKNVVPVYDLLLEMLNAHVLR
3D structure
PDB5toa An alternative conformation of ER beta bound to estradiol reveals H12 in a stable antagonist position.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST A L298 E305 M336 F356 G472 H475 L476 L36 E43 M74 F94 G201 H204 L205 BindingDB: IC50=1.1nM,Kd=0.5nM,EC50=2.1nM,Ki=0.015nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:5toa, PDBe:5toa, PDBj:5toa
PDBsum5toa
PubMed28615710
UniProtQ92731|ESR2_HUMAN Estrogen receptor beta (Gene Name=ESR2)

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