Structure of PDB 5tmw Chain A

Receptor sequence
>5tmwA (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
KKNSLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLAD
RELVHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGK
LLFAPNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSI
ILLNSGVYTFLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLL
LILSHIRHMSNKGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5tmw Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainA
Resolution2.286 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 D538 E542 I57 K61 L71 V75 D230 E234
BS02 7FP A M343 L346 T347 E353 L387 L391 F404 V418 E419 M421 I424 H524 L525 M42 L45 T46 E52 L86 L90 F103 V117 E118 M120 I123 H216 L217
External links
PDB RCSB:5tmw, PDBe:5tmw, PDBj:5tmw
PDBsum5tmw
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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