Structure of PDB 5tm9 Chain A

Receptor sequence

>5tm9A (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYS

3D structure

PDB

5tm9 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	I358 K362 L372 V376	I54 K58 L68 V72
BS02	7KL	A	T347 E353 M388 I424	T43 E49 M84 I120
BS03	7KL	A	F337 Q414	F33 Q110
BS04	7KL	A	Y331 P333 R335 P336 F337 S338 S341 M342 N407 Q414	Y27 P29 R31 P32 F33 S34 S37 M38 N103 Q110
BS05	7KL	A	Y331 P333 R335 P336 F337 S338 S341 M342 N407 L410 Q414	Y27 P29 R31 P32 F33 S34 S37 M38 N103 L106 Q110

External links

PDB	RCSB:5tm9, PDBe:5tm9, PDBj:5tm9
PDBsum	5tm9
PubMed	28042045
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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