Structure of PDB 5tm8 Chain A

Receptor sequence
>5tm8A (length=235) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFKSLEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLL
ILSHIRHMSNKGMEHLYSMKCPLSDLLLEMLDAHR
3D structure
PDB5tm8 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainA
Resolution1.99 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 L372 V376 E380 D538 E542 I54 K58 L68 V72 E76 D225 E229
BS02 7K6 A M343 L346 T347 E353 L387 M421 H524 L525 K529 L536 L540 M39 L42 T43 E49 L83 M117 H215 L216 K220 L223 L227
External links
PDB RCSB:5tm8, PDBe:5tm8, PDBj:5tm8
PDBsum5tm8
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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