Structure of PDB 5tm4 Chain A

Receptor sequence

>5tm4A (length=228) Species: 9606 (Homo sapiens) [Search protein sequence]

SLALSLTADQMVSALLDAEPPILYSEYDPTRPFSEASMMGLLTNLADREL
VHMINWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLF
APNLLLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILL
NSGVYTFEEKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILS
HIRHMSNKGMEHLYSMSDLLLEMLDAHR

3D structure

PDB

5tm4 Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

Chain

Resolution

2.25 Å

3D
structure

[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]

Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	peptide	A	I358 K362 L372 V376 D538 L539 E542	I54 K58 L68 V72 D218 L219 E222
BS02	7E3	A	Y331 D332 P333 R335 P336 F337 S341 M342 N407 L408 L410 Q414	Y27 D28 P29 R31 P32 F33 S37 M38 N103 L104 L106 Q110
BS03	7E3	A	F337 Q414	F33 Q110
BS04	7E3	A	M343 A350 E353 M388 F404 M421 I424 G521 H524 L525 M528 L540	M39 A46 E49 M84 F100 M117 I120 G209 H212 L213 M216 L220

External links

PDB	RCSB:5tm4, PDBe:5tm4, PDBj:5tm4
PDBsum	5tm4
PubMed	28042045
UniProt	P03372\|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]