Structure of PDB 5tlu Chain A

Receptor sequence
>5tluA (length=229) Species: 9606 (Homo sapiens) [Search protein sequence]
SLALSLTADQMVSALLDAEPPILYSEYPFSEASMMGLLTNLADRELVHMI
NWAKRVPGFVDLTLHDQVHLLECAWLEILMIGLVWRSMEHPGKLLFAPNL
LLDRNQGKCVEGMVEIFDMLLATSSRFRMMNLQGEEFVCLKSIILLNSGV
YTKDHIHRVLDKITDTLIHLMAKAGLTLQQQHQRLAQLLLILSHIRHMSN
KGMEHLYSMKCKNVVPLSDLLLEMLDAHR
3D structure
PDB5tlu Systems Structural Biology Analysis of Ligand Effects on ER alpha Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.
ChainA
Resolution2.223 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I358 K362 V376 E380 D538 L539 E542 I50 K54 V68 E72 D219 L220 E223
BS02 7EE A M343 E353 L387 M421 G521 H524 L525 M35 E45 L79 M113 G202 H205 L206 BindingDB: EC50=10nM
External links
PDB RCSB:5tlu, PDBe:5tlu, PDBj:5tlu
PDBsum5tlu
PubMed28042045
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

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