Structure of PDB 5tl8 Chain A

Receptor sequence

>5tl8A (length=450) Species: 5763 (Naegleria fowleri) [Search protein sequence]

KLPPRVPNLIPYVGSFVSFAKNPVQFIIDNSKKYGDVFTATILGKEMTFL
NHPKILDTFFKATDNELSLRDVYRFMRPVFGTGVVYDADSTERMMEQVKF
VSSGLTTARFRVFVDIFEDEIAHKVKELGPEGTVDVAELMADLIIFTASR
CLLGDEVRQYLSEKNLGKLYHDIDDGISPLSFFYPSLPAPKRDKARKAVG
EIFQELLDKRREEHKKHPERLLDESKMDVVDHLLTQKYKDGQELTDVHRI
GILIAGLFAGQHTSSITSSWTLMNVISNKKVLEKVRKEQEEIMGSDKVLD
YDKVMKMDYLEACMKEALRMYPPLIMIMRMARKPRECEQYIIPKGNILVV
SPSVAGRCTDTYTNPDVFDPERLTERKEHEKFKYGAVPFGAGRHKCIGEN
FALLQVKSIISILLRYFDMEYIGKIPDPSYTSLVVGPSPPTRMRYKLRKQ

3D structure

PDB

5tl8 Structure of the Naegleria fowleri CYP51 at 1.7 Angstroms resolution

Chain

Resolution

1.71 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	HEM	A	Y107 Y120 A293 T297 P357 L358 R363 P422 F423 H428 C430 I431 G432 F435 A436	Y73 Y86 A259 T263 P323 L324 R329 P388 F389 H394 C396 I397 G398 F401 A402
BS02	X2N	A	F53 A54 Y107 F114 Y120 P213 L214 F216 A289 F292 A293 T297 L358 M360 Y464 T465 L467	F19 A20 Y73 F80 Y86 P179 L180 F182 A255 F258 A259 T263 L324 M326 Y430 T431 L433
BS03	CA	A	L43 S49 V51 S52	L9 S15 V17 S18
BS04	CA	A	L84 V384 S385	L50 V350 S351

Gene Ontology

	Molecular Function
GO:0004497	monooxygenase activity
GO:0005506	iron ion binding
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037	heme binding
GO:0046872	metal ion binding

View graph for
Molecular Function

External links

PDB	RCSB:5tl8, PDBe:5tl8, PDBj:5tl8
PDBsum	5tl8
PubMed
UniProt	A0A2H4A2U9

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