Structure of PDB 5tkd Chain A

Receptor sequence
>5tkdA (length=248) Species: 9606 (Homo sapiens) [Search protein sequence]
FHRVDQKEITQLSHLGQGTRTNVYEGRLRLRVVLKVLDPSHHDIALAFYE
TASLMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVP
MAWKMVVAQQLASALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKL
SDPGVGLGALSREERVERIPWLAPECLPSTAMDKWGFGATLLEICFDGEA
PLRSPSEKEHFYQRQHRLPEPSLATLTSQCLTYEPTQRPSFRTILRDL
3D structure
PDB5tkd Identification of imidazo[1,2-b]pyridazine TYK2 pseudokinase ligands as potent and selective allosteric inhibitors of TYK2 signalling.
ChainA
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N734 R738 N739 D759
Catalytic site (residue number reindexed from 1) N127 R131 N132 D152
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7GL A L595 G596 V603 V640 K642 Y689 V690 G693 P694 R738 L741 L15 G16 V23 V33 K35 Y82 V83 G86 P87 R131 L134 PDBbind-CN: -logKd/Ki=8.15,IC50=0.007uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5tkd, PDBe:5tkd, PDBj:5tkd
PDBsum5tkd
PubMed30108788
UniProtP29597|TYK2_HUMAN Non-receptor tyrosine-protein kinase TYK2 (Gene Name=TYK2)

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