Structure of PDB 5tk5 Chain A

Receptor sequence
>5tk5A (length=283) Species: 9606 (Homo sapiens) [Search protein sequence]
RRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGE
EVFYQLEGDMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGL
VVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSE
QYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQAGTPLSL
FGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVTMGGRRLSLAPDD
SLLVLAGTSYAWERTQGSVALSVTQDPACKKPL
3D structure
PDB5tk5 Crystal structures of human 3-hydroxyanthranilate 3,4-dioxygenase with native and non-native metals bound in the active site.
ChainA
Resolution1.88 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.13.11.6: 3-hydroxyanthranilate 3,4-dioxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FE A H47 E53 H91 H45 E51 H89
Gene Ontology
Molecular Function
GO:0000334 3-hydroxyanthranilate 3,4-dioxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0008198 ferrous iron binding
GO:0009055 electron transfer activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
Biological Process
GO:0006569 tryptophan catabolic process
GO:0009435 NAD biosynthetic process
GO:0010043 response to zinc ion
GO:0019363 pyridine nucleotide biosynthetic process
GO:0019805 quinolinate biosynthetic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
GO:0043420 anthranilate metabolic process
GO:0046686 response to cadmium ion
GO:0046874 quinolinate metabolic process
GO:0070050 neuron cellular homeostasis
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:5tk5, PDBe:5tk5, PDBj:5tk5
PDBsum5tk5
PubMed28375145
UniProtP46952|3HAO_HUMAN 3-hydroxyanthranilate 3,4-dioxygenase (Gene Name=HAAO)

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