Structure of PDB 5tjh Chain A

Receptor sequence
>5tjhA (length=460) Species: 9606 (Homo sapiens) [Search protein sequence]
FEIKKICCIGAGYVGGPTCSVIAHMCPEIRVTVVDVNESRINAWNSPTLP
IYEPGLKEVVESCRGKNLFFSTNIDDAIKEADLVFISVNTPTKTYGMGKG
RAADLKYIEACARRIVQNSNGYKIVTEKSTVPVRMAESIRRIFDANTKPN
LNLQVLSNPEFLAEGTAIKDLKNPDRVLIGGDETPEGQRAVQALCAVYEH
WVPREKILTTNTWSSELSKLAANAFLAQRISSINSISALCEATGADVEEV
ATAIGMDQRIGNKFLKASVGFGGSCFQKDVLNLVYLCEALNLPEVARYWQ
QVIDMNDYQRRRFASRIIDSLFNTVTDKKIAILGFAFKKDTGDTRESSSI
YISKYLMDEGAHLHIYDPKVPREQIVVDLSHDQVSRLVTISKDPYEACDG
AHAVVICTEWDMFKELDYERIHKKMLKPAFIFDGRRVLDGLHNELQTIGF
QIETIGKKVS
3D structure
PDB5tjh Allostery and Hysteresis Are Coupled in Human UDP-Glucose Dehydrogenase.
ChainA
Resolution2.05 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) T131 E165 K220 N224 C276 D280
Catalytic site (residue number reindexed from 1) T130 E164 K219 N223 C275 D279
Enzyme Commision number 1.1.1.22: UDP-glucose 6-dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 POP A F272 G273 F277 F338 F271 G272 F276 F337
Gene Ontology
Molecular Function
GO:0003979 UDP-glucose 6-dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
GO:0051287 NAD binding
Biological Process
GO:0001702 gastrulation with mouth forming second
GO:0006024 glycosaminoglycan biosynthetic process
GO:0006065 UDP-glucuronate biosynthetic process
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030206 chondroitin sulfate biosynthetic process
GO:0034214 protein hexamerization
GO:0048666 neuron development
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5tjh, PDBe:5tjh, PDBj:5tjh
PDBsum5tjh
PubMed27966912
UniProtO60701|UGDH_HUMAN UDP-glucose 6-dehydrogenase (Gene Name=UGDH)

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