Structure of PDB 5ti4 Chain A

Receptor sequence
>5ti4A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5ti4 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7CM A W81 P82 V87 L92 N140 D145 I146 M149 W40 P41 V46 L51 N99 D104 I105 M108 MOAD: ic50=26uM
PDBbind-CN: -logKd/Ki=4.59,IC50=26uM
External links
PDB RCSB:5ti4, PDBe:5ti4, PDBj:5ti4
PDBsum5ti4
PubMed28884163
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

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