Structure of PDB 5ti2 Chain A

Receptor sequence
>5ti2A (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
SMNPPPPETSNPNKPKRQTNQLQYLLRVVLKTLWKHQFAWPFQQPVDAVK
LNLPDYYKIIKTPMDMGTIKKRLENNYYWNAQECIQDFNTMFTNCYIYNK
PGDDIVLMAEALEKLFLQKINELPTEE
3D structure
PDB5ti2 Identification of a Novel Class of BRD4 Inhibitors by Computational Screening and Binding Simulations.
ChainA
Resolution1.65 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7CJ A V87 L92 L94 N140 I146 V46 L51 L53 N99 I105 MOAD: ic50=24uM
PDBbind-CN: -logKd/Ki=4.62,IC50=24uM
External links
PDB RCSB:5ti2, PDBe:5ti2, PDBj:5ti2
PDBsum5ti2
PubMed28884163
UniProtO60885|BRD4_HUMAN Bromodomain-containing protein 4 (Gene Name=BRD4)

[Back to BioLiP]