Structure of PDB 5thh Chain A

Receptor sequence
>5thhA (length=329) Species: 9606 (Homo sapiens) [Search protein sequence]
APSPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYF
VPMSKIADFLKAGCEVTILFADLHAYLDNMKAPWELLELRVSYYENVIKA
MLESIGVPLEKLKFIKGTDYQLSKEYTLDVYRLSSVVTQHDSKKAGAEVV
KQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAKKYLPALG
YSKRVHLMNPMVPGLTGKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSF
IKHVLFPLKSEFVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSV
EVALNKLLDPIREKFNTPALKKLASAAYP
3D structure
PDB5thh Alternative stable conformation capable of protein misinteraction links tRNA synthetase to peripheral neuropathy.
ChainA
Resolution1.959 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.1.1.1: tyrosine--tRNA ligase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TYR A Y39 G41 L72 A74 H77 V152 Y166 Q170 D173 Q188 Y36 G38 L69 A71 H74 V149 Y163 Q167 D170 Q185
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004831 tyrosine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006437 tyrosyl-tRNA aminoacylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5thh, PDBe:5thh, PDBj:5thh
PDBsum5thh
PubMed28531329
UniProtP54577|SYYC_HUMAN Tyrosine--tRNA ligase, cytoplasmic (Gene Name=YARS1)

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