Structure of PDB 5th6 Chain A

Receptor sequence
>5th6A (length=220) Species: 9606 (Homo sapiens) [Search protein sequence]
DRQLAEEYLYRYGYTRVALGPALLLLQKQLSLPETGELDSATLKAMRTPR
CGVPDLGRFQTFEGDLKWHHHNITYWIQNYSEDLPRAVIDDAFARAFALW
SAVTPLTFTRVYSRDADIVIQFGVAEHGDGYPFDGKDGLLAHAFPPGPGI
QGDAHFDDDELWSLGKGQGYSLFLVAAHEFGHALGLDHSSVPEALMYPMY
RFTEGPPLHKDDVNGIRHLY
3D structure
PDB5th6 Biochemical characterization and structure determination of a potent, selective antibody inhibitor of human MMP9.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H401 E402 H405 H411
Catalytic site (residue number reindexed from 1) H178 E179 H182 H188
Enzyme Commision number 3.4.24.35: gelatinase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C99 H401 H405 H411 C51 H178 H182 H188
BS02 ZN A H175 D177 H190 H203 H127 D129 H142 H155
BS03 CA A D165 G197 Q199 D201 D117 G149 Q151 D153
BS04 CA A D182 G183 D185 L187 D205 E208 D134 G135 D137 L139 D157 E160
BS05 CA A D131 D206 E208 D83 D158 E160
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5th6, PDBe:5th6, PDBj:5th6
PDBsum5th6
PubMed28235803
UniProtP14780|MMP9_HUMAN Matrix metalloproteinase-9 (Gene Name=MMP9)

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