Structure of PDB 5tg7 Chain A

Receptor sequence
>5tg7A (length=244) Species: 470 (Acinetobacter baumannii) [Search protein sequence]
HISSQQHEKAIKSYFDEAQTQGVIIIKEGKNLSTYGNALARANKEYVPAS
TFKMLNALIGLENHKATTNEIFKWDGKKRTYPPWEKDMTLGEAMALSAVP
VYQELARRTGLELMQKEVKRVNFGNTNIGTQVDNFWLVGPLKITPVQEVN
FADDLAHNRLPFKLETQEEVKKMLLIKEVNGSKIYAKSGWGMGVTPQVGW
LTGWVEQANGKKIPFSLNLEMKEGMSGSIRNEITYKSLENLGII
3D structure
PDB5tg7 Exploring the potential of boronic acids as inhibitors of OXA-24/40 beta-lactamase.
ChainA
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S81 K84 S128 Y133 W167 W221
Catalytic site (residue number reindexed from 1) S50 K53 S97 Y102 W136 W190
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 JW3 A S81 S128 L168 W221 M223 S50 S97 L137 W190 M192 PDBbind-CN: -logKd/Ki=4.53,Ki=29.8uM
BS02 MEE A X114 L127 X83 L96
Gene Ontology
Molecular Function
GO:0008658 penicillin binding
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
Biological Process
GO:0071555 cell wall organization

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Molecular Function
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Biological Process
External links
PDB RCSB:5tg7, PDBe:5tg7, PDBj:5tg7
PDBsum5tg7
PubMed27997706
UniProtQ8RLA6

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