Structure of PDB 5tg2 Chain A

Receptor sequence
>5tg2A (length=162) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
PPTLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAIHQ
AGEFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRM
GAIASMRIQGRLVHGQSGMLLTGANAKGDCGAPYVHKRGNDWVVCGVHAA
ATGNTVVCAVQA
3D structure
PDB5tg2 Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.
ChainA
Resolution1.75 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V69 A H30 I109 Q110 C139 A158 A159 A160 H29 I108 Q109 C130 A149 A150 A151 PDBbind-CN: -logKd/Ki=5.49,IC50=3.2uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5tg2, PDBe:5tg2, PDBj:5tg2
PDBsum5tg2
PubMed28038326
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

[Back to BioLiP]