Structure of PDB 5tg1 Chain A

Receptor sequence
>5tg1A (length=166) Species: 524364 (Norovirus Hu/1968/US) [Search protein sequence]
TLWSRVTKFGSGWGFWVSPTVFITTTHVVPTGVKEFFGEPLSSIAIHQAG
EFTQFRFSKKMRPDLTGMVLEEGCPEGTVCSVLIKRDSGELLPLAVRMGA
IASMRIQGRLVHGQSGMLLANAKGMDLGTIPGDCGAPYVHKRGNDWVVCG
VHAAATKSNTVVCAVQ
3D structure
PDB5tg1 Design, synthesis, and evaluation of a novel series of macrocyclic inhibitors of norovirus 3CL protease.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.66: calicivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 V56 A H30 I109 Q110 G133 T134 I135 P136 C139 A158 A159 A160 H27 I106 Q107 G128 T129 I130 P131 C134 A153 A154 A155 PDBbind-CN: -logKd/Ki=5.82,IC50=1.5uM
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5tg1, PDBe:5tg1, PDBj:5tg1
PDBsum5tg1
PubMed28038326
UniProtQ83883|POLG_NVN68 Genome polyprotein (Gene Name=ORF1)

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