Structure of PDB 5tfr Chain A

Receptor sequence
>5tfrA (length=882) Species: 64320 (Zika virus) [Search protein sequence]
ETLGEKWKARLNQMSALEFYSYKKSGITEVCREEARRALKDGVATGGHAV
SRGSAKIRWLEERGYLQPYGKVVDLGCGRGGWSYYAATIRKVQEVRGYTK
GGPGHEEPMLVQSYGWNIVRLKSGVDVFHMAAEPCDTLLCDIGESSSSPE
VEETRTLRVLSMVGDWLEKRPGAFCIKVLCPYTSTMMETMERLQRRHGGG
LVRVPLCRNSTHEMYWVSGAKSNIIKSVSTTSQLLLGRMDGPRRPVKYEE
DVNLGSGTRAVASCAEAPNMKIIGRRIERIRNEHAETWFLDENHPYRTWA
YHGSYEAPTQGSASSLVNGVVRLLSKPWDVVTGVTGIAMTDTTPYGQQRV
FKEKVDTRVPDPQEGTRQVMNIVSSWLWKELGKRKRPRVCTKEEFINKVR
SNAALGAIFEEEKEWKTAVEAVNDPRFWALVDREREHHLRGECHSCVYNM
MGKREKKQGEFGKAKGSRAIWYMWLGARFLEFEALGFLNEDHWMGRENSG
GGVEGLGLQRLGYILEEMNRAPGGKMYADDTAGWDTRISKFDLENEALIT
NQMEEGHRTLALAVIKYTYQNKVVKVLRPAEGGKTVMDIISRQDQRGSGQ
VVTYALNTFTNLVVQLIRNMEAEEVLEMQDLWLLRKPEKVTRWLQSNGWD
RLKRMAVSGDDCVVKPIDDRFAHALRFLNDMGKVRKDTQEWKPSTGWSNW
EEVPFCSHHFNKLYLKDGRSIVVPCRHQDELIGRARVSPGAGWSIRETAC
LAKSYAQMWQLLYFHRRDLRLMANAICSAVPVDWVPTGRTTWSIHGKGEW
MTTEDMLMVWNRVWIEENDHMEDKTPVTKWTDIPYLGKREDLWCGSLIGH
RPRTTWAENIKDTVNMVRRIIGDEEKYMDYLS
3D structure
PDB5tfr Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
ChainA
Resolution3.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A S56 G81 G86 W87 K105 H110 V130 D131 V132 F133 D146 S51 G76 G81 W82 K100 H105 V125 D126 V127 F128 D141
BS02 ZN A E439 H443 C448 C451 E434 H438 C443 C446
BS03 ZN A H714 C730 C849 H709 C725 C844
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0004482 mRNA 5'-cap (guanine-N7-)-methyltransferase activity
GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity
GO:0005524 ATP binding
GO:0008168 methyltransferase activity
Biological Process
GO:0032259 methylation
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5tfr, PDBe:5tfr, PDBj:5tfr
PDBsum5tfr
PubMed28291746
UniProtQ32ZE1|POLG_ZIKV Genome polyprotein

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