Structure of PDB 5tfm Chain A

Receptor sequence

>5tfmA (length=320) Species: 9606 (Homo sapiens) [Search protein sequence]

NVPTFQKDAYVGALRENEPSVTQLVRLRATDEDQITYSIVSASAFGSYFD
ISLYEGYGVISVSRPLDYEQISNGLIYLTVMAMDAGNPPLNSTVPVTIEV
FDENDNPPTFSKPAYFVSVVENIMAGATVLFLNATDLDRSREYGQESIIY
SLEGSTQFRINARSGEITTTSLLDRETKSEYILIVRAVDGGVGHNQKTGI
ATVNITLLDINDNHPTWKDAPYYINLVEMTPPDSDVTTVVAVDPDLGENG
TLVYSIQPPNKFYSLNSTTGKIRTTHAMLDRENPDPHEAELMRKIVVSVT
DCGRPPLKATSSATVFVNLL

3D structure

PDB

5tfm Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.

Chain

Resolution

2.92 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)
BS01	CA	A	N642 N644 D674 D676 Y681 D727	N104 N106 D136 D138 Y143 D189
BS02	CA	A	E549 E607 D640 E641 D643 D676	E16 E69 D102 E103 D105 D138
BS03	CA	A	E549 N550 D605 E607 D643	E16 N17 D67 E69 D105
BS04	CA	A	E659 E714 D747 I748 D750 D783	E121 E176 D209 I210 D212 D245
BS05	CA	A	N749 N751 D781 D783 N787 D839	N211 N213 D243 D245 N249 D301

Gene Ontology

	Molecular Function
GO:0005509	calcium ion binding

	Biological Process
GO:0007155	cell adhesion
GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609	cell-cell adhesion

	Cellular Component
GO:0005886	plasma membrane
GO:0016020	membrane

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5tfm, PDBe:5tfm, PDBj:5tfm
PDBsum	5tfm
PubMed	30033219
UniProt	Q9H251\|CAD23_HUMAN Cadherin-23 (Gene Name=CDH23)

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