Structure of PDB 5tfk Chain A

Receptor sequence

>5tfkA (length=335) Species: 10090 (Mus musculus)

ENDNHPLFTEGTYQAEVMENSPAGTPLTVLNGPILALDADEDVYAVVTYQ
LLGTHSDLFVIDNSTGVVTVRSGIIIDREAFSPPFLELLLLAEDIGQLNG
TAHLFITILDDNDNWPTFSPPTYTVHLLENCPPGFSVLQVTATDEDSGLN
GELVYRIEAGAQDRFLIHPVTGVIRVGNATIDREEQESYRLTVVATDRGT
VPLSGTAIVTILIDDINDSRPEFLNPIQTVSVLESAEPGTIIANVTAIDL
DLNPKLEYHIISIVAKDDTDRLVPDQEDAFAVNINTGSVMVKSPLNRELV
ATYEVTLSVIDNASDLPEHSVSVPNAKLTVNILDV

3D structure

• PDB: 5tfk Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
• Chain: A
• Resolution: 2.8 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	N1930 N1932 D1966 D1968 Y1972 D2022	N2 N4 D38 D40 Y44 D94
BS02	CA	A	E1947 D2005 E2007 D2041	E19 D77 E79 D113
BS03	CA	A	E1947 E2007 D2038 D2039 D2041 D2074	E19 E79 D110 D111 D113 D146
BS04	CA	A	E2162 D2262 V2263	E234 D334 V335
BS05	CA	A	N2040 N2042 D2072 D2074 N2078 D2125	N112 N114 D144 D146 N150 D197
BS06	CA	A	E2057 D2110 E2112 D2146	E129 D182 E184 D218
BS07	CA	A	E2057 E2112 D2143 I2144 D2146 D2179	E129 E184 D215 I216 D218 D251
BS08	CA	A	N2145 S2147 D2177 D2179 D2239	N217 S219 D249 D251 D311

Gene Ontology

Molecular Function

• GO:0005509 calcium ion binding

Biological Process

• GO:0007155 cell adhesion
• GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
• GO:0098609 cell-cell adhesion

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5tfk, PDBe:5tfk, PDBj:5tfk
• PDBsum: 5tfk
• PubMed: 30033219
• UniProt: Q99PF4|CAD23_MOUSE Cadherin-23 (Gene Name=Cdh23)