Structure of PDB 5tfa Chain A

Receptor sequence
>5tfaA (length=216) Species: 9606 (Homo sapiens) [Search protein sequence]
TEVVMENVTAFWEEGGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMI
MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVI
KACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLL
DSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHE
GSSYFYGTFSELQNLQ
3D structure
PDB5tfa Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
ChainA
Resolution1.87 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.1.6: channel-conductance-controlling ATPase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DUT A W401 V440 T460 G461 G463 K464 T465 S466 Q493 W12 V19 T39 G40 G42 K43 T44 S45 Q72
BS02 MG A T465 Q493 T44 Q72
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity

View graph for
Molecular Function
External links
PDB RCSB:5tfa, PDBe:5tfa, PDBj:5tfa
PDBsum5tfa
PubMed
UniProtP13569|CFTR_HUMAN Cystic fibrosis transmembrane conductance regulator (Gene Name=CFTR)

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