Structure of PDB 5tet Chain A

Receptor sequence
>5tetA (length=418) Species: 9606 (Homo sapiens) [Search protein sequence]
SAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLL
SQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGF
LKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHAQKLLVGVDEKLNPE
DIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVY
VLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGAS
LKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSE
QQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRD
YQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTA
IVGMALGHRPIPENLYFQ
3D structure
PDB5tet Binding of hydroxycitrate to human ATP-citrate lyase.
ChainA
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7A3 A G309 A345 N346 F347 T348 R379 G296 A332 N333 F334 T335 R366 BindingDB: Ki=300000nM,IC50=150nM
Gene Ontology
Molecular Function
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

View graph for
Molecular Function
External links
PDB RCSB:5tet, PDBe:5tet, PDBj:5tet
PDBsum5tet
PubMed28777081
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

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