Structure of PDB 5teq Chain A

Receptor sequence
>5teqA (length=736) Species: 9606 (Homo sapiens) [Search protein sequence]
SAKAISEQTGKELLYKFISTTSAIQNRFKYARVTPDTDWARLLQDHPWLL
SQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGF
LKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHAQKLLVGVDEKLNPED
IKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYV
LDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASL
KLTLLNPKGRIWTMVAGGGASVVYSDTIGDLGGVNELANYGEYSGAPSEQ
QTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDY
QGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAI
VGMALGHRPIGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSV
AAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLR
SAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATV
GGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISR
TTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYK
ICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKN
QALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVP
3D structure
PDB5teq Binding of hydroxycitrate to human ATP-citrate lyase.
ChainA
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) E718 H760
Catalytic site (residue number reindexed from 1) E642 H684
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC A A345 N346 F347 T348 R379 V626 A331 N332 F333 T334 R365 V550
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

View graph for
Molecular Function
External links
PDB RCSB:5teq, PDBe:5teq, PDBj:5teq
PDBsum5teq
PubMed28777081
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

[Back to BioLiP]