Structure of PDB 5teg Chain A

Receptor sequence
>5tegA (length=160) Species: 9606 (Homo sapiens) [Search protein sequence]
KSKAELQSEERKRIDELIESGKEEGMKIDLIDGKGRGVIATKQFSRGDFV
VEYHGDLIEITDAKKREALYAQDPSTGCYMYYFQYLSKTYCVDATRETNR
LGRLINHSKSGNCQTKLHDIDGVPHLILIASRDIAAGEELLYDYGDRSKA
SIEAHPWLKH
3D structure
PDB5teg Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.
ChainA
Resolution1.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.-
2.1.1.361: [histone H4]-lysine(20) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A E259 Y262 C270 M272 Y273 Y274 T307 Y334 D335 Y336 G337 D338 A342 S343 H347 E67 Y70 C78 M80 Y81 Y82 T115 Y142 D143 Y144 G145 D146 A150 S151 H155
BS02 SAM A K226 R228 Y271 R295 L296 N298 H299 Y336 W349 K34 R36 Y79 R103 L104 N106 H107 Y144 W157
Gene Ontology
Molecular Function
GO:0042799 histone H4K20 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:5teg, PDBe:5teg, PDBj:5teg
PDBsum5teg
PubMed27994746
UniProtQ9NQR1|KMT5A_HUMAN N-lysine methyltransferase KMT5A (Gene Name=KMT5A)

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