Structure of PDB 5te1 Chain A

Receptor sequence
>5te1A (length=742) Species: 9606 (Homo sapiens) [Search protein sequence]
SAKAISEQTGKELLYKFISTTSAIQNRFKYARVTPDTDWARLLQDHPWLL
SQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGF
LKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEAQKLLVGVDEKLNP
EDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGV
YVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGA
SLKLTLLNPKGRIWTMVAGGGASVVYSDTIGDLGGVNELANYGEYSGAPS
EQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIR
DYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMT
AIVGMALGHRPIPLQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSR
DEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLIN
FASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTII
GPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELN
NIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGG
TEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASET
AVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPA
3D structure
PDB5te1 Binding of hydroxycitrate to human ATP-citrate lyase.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E718 H760
Catalytic site (residue number reindexed from 1) E647 H689
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7A2 A A345 N346 F347 T348 R379 A333 N334 F335 T336 R367
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

View graph for
Molecular Function
External links
PDB RCSB:5te1, PDBe:5te1, PDBj:5te1
PDBsum5te1
PubMed28777081
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

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