Structure of PDB 5tdz Chain A

Receptor sequence
>5tdzA (length=418) Species: 9606 (Homo sapiens) [Search protein sequence]
SAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLL
SQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGF
LKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHAQKLLVGVDEKLNPE
DIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVY
VLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGAS
LKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSE
QQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRD
YQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTA
IVGMALGHRPIPENLYFQ
3D structure
PDB5tdz Binding of hydroxycitrate to human ATP-citrate lyase.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A V56 K58 R65 R66 G67 F110 V111 P204 L215 D216 V55 K57 R64 R65 G66 F109 V110 P191 L202 D203 MOAD: Ki=150uM
BS02 MG A N203 D216 N190 D203
BS03 ADN A D39 R42 L43 D38 R41 L42
Gene Ontology
Molecular Function
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

View graph for
Molecular Function
External links
PDB RCSB:5tdz, PDBe:5tdz, PDBj:5tdz
PDBsum5tdz
PubMed28777081
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

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