Structure of PDB 5tdi Chain A

Receptor sequence
>5tdiA (length=215) Species: 9606 (Homo sapiens) [Search protein sequence]
APDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLAP
QNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNP
TGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVY
YDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNK
NNACGIANLASFPKM
3D structure
PDB5tdi Identification of mouse cathepsin K structural elements that regulate the potency of odanacatib.
ChainA
Resolution1.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H162 N182
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.38: cathepsin K.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7AS A G23 C25 E59 N60 D61 G64 G65 G66 Y67 A134 L160 N161 H162 A163 G23 C25 E59 N60 D61 G64 G65 G66 Y67 A134 L160 N161 H162 A163 PDBbind-CN: -logKd/Ki=9.74,Ki=0.18nM
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:5tdi, PDBe:5tdi, PDBj:5tdi
PDBsum5tdi
PubMed28049758
UniProtP43235|CATK_HUMAN Cathepsin K (Gene Name=CTSK)

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