Structure of PDB 5tdf Chain A

Receptor sequence
>5tdfA (length=421) Species: 9606 (Homo sapiens) [Search protein sequence]
SAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLL
SQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGF
LKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGAQKLLVGVDEKL
NPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKD
GVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKS
GASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGA
PSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRA
IRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETH
MTAIVGMALGHRPIPENLYFQ
3D structure
PDB5tdf Binding of hydroxycitrate to human ATP-citrate lyase.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7A3 A S308 G309 A345 N346 F347 T348 R379 S298 G299 A335 N336 F337 T338 R369 BindingDB: Ki=300000nM,IC50=150nM
BS02 ADP A V56 K58 R66 G67 F110 V111 H113 P204 L215 D216 V55 K57 R65 G66 F109 V110 H112 P194 L205 D206 MOAD: Ki=150uM
BS03 MG A N203 D216 N193 D206
BS04 ADE A D39 R42 L43 D38 R41 L42
Gene Ontology
Molecular Function
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

View graph for
Molecular Function
External links
PDB RCSB:5tdf, PDBe:5tdf, PDBj:5tdf
PDBsum5tdf
PubMed28777081
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

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