Structure of PDB 5tde Chain A

Receptor sequence
>5tdeA (length=420) Species: 9606 (Homo sapiens) [Search protein sequence]
SAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLL
SQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGF
LKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEKAQKLLVGVDEKLN
PEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDG
VYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSG
ASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAP
SEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAI
RDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHM
TAIVGMALGHRPIPENLYFQ
3D structure
PDB5tde Binding of hydroxycitrate to human ATP-citrate lyase.
ChainA
Resolution1.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.3.8: ATP citrate synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FLC A G309 A345 N346 F347 T348 R379 G298 A334 N335 F336 T337 R368
BS02 2HP A K64 R65 R66 D216 K63 R64 R65 D205
BS03 2HP A G281 G282 G283 G270 G271 G272
Gene Ontology
Molecular Function
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer

View graph for
Molecular Function
External links
PDB RCSB:5tde, PDBe:5tde, PDBj:5tde
PDBsum5tde
PubMed28777081
UniProtP53396|ACLY_HUMAN ATP-citrate synthase (Gene Name=ACLY)

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