Structure of PDB 5tdb Chain A

Receptor sequence
>5tdbA (length=70) Species: 9606 (Homo sapiens) [Search protein sequence]
LCGRVFKVGEPTYSCRDCAVDPTCVLCMECFLGSIHRDHRYRMTTSGGGG
FCDCGDTEAWKEGPYCQKHE
3D structure
PDB5tdb Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.
ChainA
Resolution1.101 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D118 T120 C121 V122 G147 F148 D150 E155 A156 D21 T23 C24 V25 G50 F51 D53 E58 A59
BS02 ZN A C99 C124 C127 C149 C2 C27 C30 C52
BS03 ZN A C127 C151 C163 H166 C30 C54 C66 H69
BS04 ZN A C112 C115 H133 H136 C15 C18 H36 H39
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5tdb, PDBe:5tdb, PDBj:5tdb
PDBsum5tdb
PubMed28392261
UniProtQ8IWV8|UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 (Gene Name=UBR2)

[Back to BioLiP]