Structure of PDB 5td5 Chain A

Receptor sequence
>5td5A (length=179) Species: 9606 (Homo sapiens) [Search protein sequence]
RYLMDPDTFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHMGFLCNES
GRHAALRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQEN
THVRLRIKAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVY
RQGCPFQPWDGLEEHSQALSGRLRAILQL
3D structure
PDB5td5 Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B.
ChainA
Resolution1.718 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.5.4.38: single-stranded DNA cytosine deaminase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A I209 R211 H212 K213 T214 N240 H253 W281 S282 Y313 D314 Y315 I17 R19 H20 K21 T22 N48 H53 W81 S82 Y113 D114 Y115
BS02 ZN A H253 C284 C289 H53 C84 C89
Gene Ontology
Molecular Function
GO:0003824 catalytic activity

View graph for
Molecular Function
External links
PDB RCSB:5td5, PDBe:5td5, PDBj:5td5
PDBsum5td5
PubMed27991903
UniProtQ9UH17|ABC3B_HUMAN DNA dC->dU-editing enzyme APOBEC-3B (Gene Name=APOBEC3B)

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