Structure of PDB 5td2 Chain A

Receptor sequence
>5td2A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMAACMK
DFSHPNVMRLLGVCIEMSSPMVILPFMKYGDLHTYLLYSRLETGPKHIPL
QTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFPVKWI
AIESLYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQ
PEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESL
3D structure
PDB5td2 Structure-based optimization of 1H-imidazole-2-carboxamides as Axl kinase inhibitors utilizing a Mer mutant surrogate.
ChainA
Resolution2.68 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D723 A725 R727 N728 D741
Catalytic site (residue number reindexed from 1) D126 A128 R130 N131 D144
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 7AE A E595 G596 A617 K619 M650 L671 F673 M674 K675 N728 M730 E19 G20 A41 K43 M58 L74 F76 M77 K78 N131 M133 PDBbind-CN: -logKd/Ki=8.66,IC50=2.2nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5td2, PDBe:5td2, PDBj:5td2
PDBsum5td2
PubMed28082036
UniProtQ12866|MERTK_HUMAN Tyrosine-protein kinase Mer (Gene Name=MERTK)

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