Structure of PDB 5tcx Chain A

Receptor sequence
>5tcxA (length=208) Species: 9606 (Homo sapiens) [Search protein sequence]
STKSIKYLLFVFNFVFWLAGGVILGVALWLRHPNTFYVGIYILIAVGAVM
MFVGFLGCYGAIQQCLLGTFFTCLVILFACEVAAGIWGFVNKDQIAKDVK
QFYDQALQQAVVDDDANNAKAVVKTFHETLDCCGSSTLTALTTSVLKNNL
CPSGSNIISNLFKEDCHQKIDDLFSGKLYLIGIAAIVVAVIMIFEMILSM
VLSSGIRN
3D structure
PDB5tcx Crystal Structure of a Full-Length Human Tetraspanin Reveals a Cholesterol-Binding Pocket.
ChainA
Resolution2.955 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 CLR A F21 V68 M72 V75 L101 E219 F16 V46 M50 V53 L77 E195
Gene Ontology
Molecular Function
GO:0001618 virus receptor activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0015485 cholesterol binding
GO:0023026 MHC class II protein complex binding
GO:0042289 MHC class II protein binding
GO:1990459 transferrin receptor binding
Biological Process
GO:0001771 immunological synapse formation
GO:0002250 adaptive immune response
GO:0002455 humoral immune response mediated by circulating immunoglobulin
GO:0002863 positive regulation of inflammatory response to antigenic stimulus
GO:0014905 myoblast fusion involved in skeletal muscle regeneration
GO:0030890 positive regulation of B cell proliferation
GO:0031623 receptor internalization
GO:0031647 regulation of protein stability
GO:0034238 macrophage fusion
GO:0035783 CD4-positive, alpha-beta T cell costimulation
GO:0043410 positive regulation of MAPK cascade
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046718 symbiont entry into host cell
GO:0050861 positive regulation of B cell receptor signaling pathway
GO:0050862 positive regulation of T cell receptor signaling pathway
GO:0050871 positive regulation of B cell activation
GO:0061462 protein localization to lysosome
GO:0070863 positive regulation of protein exit from endoplasmic reticulum
GO:0071404 cellular response to low-density lipoprotein particle stimulus
GO:0072659 protein localization to plasma membrane
GO:0072675 osteoclast fusion
GO:1903911 positive regulation of receptor clustering
GO:1904352 positive regulation of protein catabolic process in the vacuole
GO:1905521 regulation of macrophage migration
GO:1905676 positive regulation of adaptive immune memory response
GO:2000145 regulation of cell motility
GO:2000553 positive regulation of T-helper 2 cell cytokine production
GO:2000563 positive regulation of CD4-positive, alpha-beta T cell proliferation
GO:2001190 positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Cellular Component
GO:0001772 immunological synapse
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0009925 basal plasma membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0031982 vesicle
GO:0070062 extracellular exosome
GO:0097197 tetraspanin-enriched microdomain

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5tcx, PDBe:5tcx, PDBj:5tcx
PDBsum5tcx
PubMed27881302
UniProtP60033|CD81_HUMAN CD81 antigen (Gene Name=CD81)

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