Structure of PDB 5tcd Chain A

Receptor sequence
>5tcdA (length=388) Species: 9606 (Homo sapiens) [Search protein sequence]
QNKLLLVSFDGFRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCH
FTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRWWDNGSVPIWIT
AQRQGLRAGSFFYPGGNVTYQGVAVTRSRKEGIAHNYKNETEWRANIDTV
MAWFTEEDLDLVTLYFGEPDSTGHRYGPESPERREMVRQVDRTVGYLRES
IARNHLTDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIEFELLD
YGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKEAFPEAFHYANNPRVTP
LLMYSDLGYVIHGRINVQFNNGEHGFDNKDMDMKTIFRAVGPSFRAGLEV
EPFESVHVYELMCRLLGIVPEANDGHLATLLPMLHTES
3D structure
PDB5tcd Crystal structure of the human alkaline sphingomyelinase provides insights into substrate recognition.
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.12: sphingomyelin phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A D39 T75 D246 H247 D10 T46 D217 H218
BS02 ZN A D199 H203 H353 D170 H174 H324
BS03 PC A D39 T75 N96 Y166 G196 D199 H203 H353 D10 T46 N67 Y137 G167 D170 H174 H324
External links
PDB RCSB:5tcd, PDBe:5tcd, PDBj:5tcd
PDBsum5tcd
PubMed28292932
UniProtQ6UWV6|ENPP7_HUMAN Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (Gene Name=ENPP7)

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