Structure of PDB 5tc3 Chain A

Receptor sequence
>5tc3A (length=488) Species: 284811 (Eremothecium gossypii ATCC 10895) [Search protein sequence]
TYRDAATALEHLATYAEKDGLSVEQLMDSKTGGLTYNDFLVLPGKIDFPS
SEVVLSSRLTKKITLNAPFVSSPMDTVTEADMAIHMALLGGIGIIHHNCT
AEEQAEMVRRVKKYENGFINAPVVVGPDATVADVRRMKNEFGFAGFPVTD
DGKPTGKLQGIITSRDIQFVEDETLLVSEIMTKDVITGKQGINLEEANQI
LKNTKKGKLPIVDEAGCLVSMLSRTDLMKNQSYPLASKSADTKQLLCGAA
IGTIDADRQRLAMLVEAGLDVVVLDSSQGNSVFQINMIKWIKETFPDLQV
IAGNVVTREQAASLIHAGADGLRIGMGSGSICITQEVMACGRPQGTAVYN
VTQFANQFGVPCIADGGVQNIGHITKAIALGASTVMMGGMLAGTTESPGE
YFRRLKTYRGSIDAAQGVTGSVIDKGSIKKYIPYLYNGLQHSCQDIGVRS
LVEFREKVDSGSVRFEFRTPSAQLEGGVHNLHSYELFD
3D structure
PDB5tc3 A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases.
ChainA
Resolution2.462 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.1.1.205: IMP dehydrogenase.
Interaction with ligand
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003938 IMP dehydrogenase activity
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0006164 purine nucleotide biosynthetic process
GO:0006177 GMP biosynthetic process
GO:0006183 GTP biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:5tc3, PDBe:5tc3, PDBj:5tc3
PDBsum5tc3
PubMed28572600
UniProtQ756Z6

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