Structure of PDB 5tbs Chain A

Receptor sequence
>5tbsA (length=284) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
TPVVANYENASMAADYIKRVSNVLPDIGIICGSGLGKLIEEIEERKVIPY
INIPNFPKTTVAGHVGNLVLGSVGGRKIVAMQGRLHMYEGYSNQEIALPI
RVMKLLGVRVLLITNLAGGINRKLKSGDFVLIKGHINFPGLGLNNVLVGP
NQDEFGPRFPDLSNAYDRLLQQLALKIAQENDFQDLVHEGVYAFNGGPTY
ESPDESNMLLKLGCDVVGMSTVPEVIIACHCGIKVLAVSLIANNSILDAE
NDVSINHEKVLAVAEKRADLLQMWFKEIITRLPL
3D structure
PDB5tbs The molecular structure of Schistosoma mansoni PNP isoform 2 provides insights into the nucleoside selectivity of PNPs.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S35 H66 H88 Y90 E91 L118 M221 S222 N245 S247 H259
Catalytic site (residue number reindexed from 1) S33 H64 H86 Y88 E89 L116 M219 S220 N243 S245 H257
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADE A A119 G120 Y202 E203 A244 N245 A117 G118 Y200 E201 A242 N243
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047975 guanosine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:5tbs, PDBe:5tbs, PDBj:5tbs
PDBsum5tbs
PubMed30192840
UniProtA0A0U3AGT1

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