Structure of PDB 5tbm Chain A

Receptor sequence
>5tbmA (length=106) Species: 9606 (Homo sapiens) [Search protein sequence]
LDSKTFLSEHSMDMKFTYCDDRITELIGYHPEELLGRSAYEFYHALDSEN
MTKSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPPQCIMCVNY
VLSEIE
3D structure
PDB5tbm A Small-Molecule Antagonist of HIF2 alpha Is Efficacious in Preclinical Models of Renal Cell Carcinoma.
ChainA
Resolution1.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 79A A F244 H248 M252 A277 Y281 H293 L296 V302 Y307 M309 T321 I337 C339 N341 F6 H10 M14 A39 Y43 H55 L58 V64 Y69 M71 T83 I95 C97 N99 MOAD: Kd=0.049uM
PDBbind-CN: -logKd/Ki=7.31,Kd=0.049uM
BindingDB: EC50=27nM,IC50=12nM
External links
PDB RCSB:5tbm, PDBe:5tbm, PDBj:5tbm
PDBsum5tbm
PubMed27635045
UniProtQ99814|EPAS1_HUMAN Endothelial PAS domain-containing protein 1 (Gene Name=EPAS1)

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