Structure of PDB 5tb6 Chain A

Receptor sequence
>5tb6A (length=119) Species: 9606 (Homo sapiens) [Search protein sequence]
SMRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDI
VKNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFC
SKLAEVFEQEIDPVMQSLG
3D structure
PDB5tb6 Discovery of New Bromodomain Scaffolds by Biosensor Fragment Screening.
ChainA
Resolution1.79 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 77X A P1110 F1111 V1115 L1120 N1168 V1174 P32 F33 V37 L42 N90 V96 MOAD: Kd=1.53uM
PDBbind-CN: -logKd/Ki=5.82,Kd=1.53uM
BindingDB: Kd=3650nM
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5tb6, PDBe:5tb6, PDBj:5tb6
PDBsum5tb6
PubMed27994766
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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