Structure of PDB 5t97 Chain A

Receptor sequence
>5t97A (length=177) Species: 9606 (Homo sapiens) [Search protein sequence]
LTADQMVSALLDAEPPILYMGLLTNLADRELVHMINWAKRVPGFVDLTLH
DQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLGMVEIFDMLLATS
SRFRMMNLQGEEFVCLKSIILLNSGHIHRVLDKITDTLIHLMAKAGLTLQ
QQHQRLAQLLLILSHIRHMSNKGMEHL
3D structure
PDB5t97 Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha + Breast Cancer.
ChainA
Resolution3.0 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 782 A T347 A350 D351 E353 M388 F404 M421 I424 H524 T24 A27 D28 E30 M65 F81 M89 I92 H176 PDBbind-CN: -logKd/Ki=7.77,IC50=17nM
BindingDB: IC50=34nM
External links
PDB RCSB:5t97, PDBe:5t97, PDBj:5t97
PDBsum5t97
PubMed28296398
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]