Structure of PDB 5t92 Chain A

Receptor sequence
>5t92A (length=183) Species: 9606 (Homo sapiens) [Search protein sequence]
LTADQMVSALLDAEPPILYSSEASMMGLLTNLADRELVHMINWAKRVPGF
VDLTLHDQVHLLESAWLEILMIGLVWRSMEHPGKLLFAPNLLLGMVEIFD
MLLATSSRFRMMNLQGEEFVCLKSIILLNSGHIHRVLDKITDTLIHLMAK
AGLTLQQQHQRLAQLLLILSHIRHMSNKGMEHL
3D structure
PDB5t92 Discovery of an Acrylic Acid Based Tetrahydroisoquinoline as an Orally Bioavailable Selective Estrogen Receptor Degrader for ER alpha + Breast Cancer.
ChainA
Resolution2.22 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 77W A T347 A350 E353 L384 L387 M388 M421 I424 H524 T30 A33 E36 L67 L70 M71 M95 I98 H182 MOAD: ic50=16nM
PDBbind-CN: -logKd/Ki=7.80,IC50=16nM
External links
PDB RCSB:5t92, PDBe:5t92, PDBj:5t92
PDBsum5t92
PubMed28296398
UniProtP03372|ESR1_HUMAN Estrogen receptor (Gene Name=ESR1)

[Back to BioLiP]