Structure of PDB 5t8s Chain A

Receptor sequence
>5t8sA (length=388) Species: 242231 (Neisseria gonorrhoeae FA 1090) [Search protein sequence]
SEYLFTSESVSEGHPDKVADQVSDAILDAILAQDPKARVAAETLVNTGLC
VLAGEITTTAQVDYIKVARETIKRIGYNSSELGFDANGCAVGVYYDQQSP
DIAQGVNEGEGIDLNQGAGDQGLMFGYACDETPTLMPFAIYYSHRLMQRQ
SELRKDGRLPWLRPDAKAQLTVVYDSETGKVKRIDTVVLSTQHDPAISQE
ELSKAVIEQIIKPVLPPELLTDETKYLINPTGRFVIGGPQGDCGLTGRKI
IVDTYGGAAPHGGGAFSGKDPSKVDRSAAYACRYVAKNIVAAGLATQCQI
QVSYAIGVAEPTSISIDTFGTGKISEEKLIALVCEHFDLRPKGIVQMLDL
LRPIYGKSAAYGHFGREEPEFTWERTDKAASLKAAAGL
3D structure
PDB5t8s Crystal Structure of a S-adenosylmethionine Synthase from Neisseria gonorrhoeae with bound S-adenosylmethionine, AMP, Pyrophosphate, Phosphate, and Magnesium
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H15 D17 K18 E43 E56 K168 F235 D243 C244 R249 K250 K270 K274 D276
Catalytic site (residue number reindexed from 1) H14 D16 K17 E42 E55 K167 F234 D242 C243 R248 K249 K269 K273 D275
Enzyme Commision number 2.5.1.6: methionine adenosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AMP A H15 P16 D166 K168 S191 F235 D243 H14 P15 D165 K167 S190 F234 D242
BS02 POP A H15 K168 K250 H14 K167 K249
BS03 SAM A E56 Q99 D102 I103 D121 K274 I307 E55 Q98 D101 I102 D120 K273 I306
BS04 3PO A D121 G265 A266 K270 D276 D120 G264 A265 K269 D275
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004478 methionine adenosyltransferase activity
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006556 S-adenosylmethionine biosynthetic process
GO:0006730 one-carbon metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:5t8s, PDBe:5t8s, PDBj:5t8s
PDBsum5t8s
PubMed
UniProtQ5FAC0|METK_NEIG1 S-adenosylmethionine synthase (Gene Name=metK)

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