Structure of PDB 5t8p Chain A

Receptor sequence
>5t8pA (length=327) Species: 10090 (Mus musculus) [Search protein sequence]
VPVEEYLVHALQGSVSSGQAHSLASLAKTWSDNEGVLLTEKLKPVDYEYR
EEVHWMTHQPRVGRGSFGEVHRMKDKQTGFQCAVKKVRLEVFRVEELVAC
AGLSSPRIVPLYGAVREGPWVNIFMELLEGGSLGQLIKQMGCLPEDRALY
YLGQALEGLEYLHTRRILHGDVKADNVLLSSDGSRAALCDFGHALCLQPD
GLSLLTGDYIPGTETHMAPEVVMGKPCDAKVDIWSSCCMMLHMLNGCHPW
TQYFRGPLCLKIASEPPPIREIPPSCAPLTAQAIQEGLRKEPVHRASAME
LRRKVGKALQEVGGLKSPWKGEYKEPR
3D structure
PDB5t8p Structure-Based Design of Tricyclic NF-kappa B Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
ChainA
Resolution2.32 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D517 K519 N522 D536 L553 T561
Catalytic site (residue number reindexed from 1) D171 K173 N176 D190 L205 T213
Enzyme Commision number 2.7.11.25: mitogen-activated protein kinase kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 774 A V416 A429 M471 L473 D521 L524 C535 D536 V70 A83 M125 L127 D175 L178 C189 D190 MOAD: Ki=1.28uM
PDBbind-CN: -logKd/Ki=5.89,Ki=1.28uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5t8p, PDBe:5t8p, PDBj:5t8p
PDBsum5t8p
PubMed28005357
UniProtQ9WUL6|M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (Gene Name=Map3k14)

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